Connection of standard each and every day sodium and potassium removal that have SBP

Connection of standard each and every day sodium and potassium removal that have SBP

Cousin regularity distribution out of (a) SBP alter, (Gaussian match Roentgen 2 getting sodium sensitive = 0.74 and you may salt resistant = 0.97) and you can (b) urinary Na + /K + randki ferzu, (Gaussian fit R 2 to possess sodium sensitive and painful = 0.99 and you may sodium resistant somebody = 0.99) about band of salt sensitive and painful (n = 71) and you will sodium resistant (letter = 119) individuals with change of dieting intervention out-of Weight reduction Methods to Stop Blood pressure (DASH) high sodium (HS) eating plan so you’re able to Dash lower sodium (LS) eating plan.

Participant demographics

Certainly one of data users assessed, 53% out-of SR and you will 62% of the SS professionals was indeed female, 51% off SR and you will 63% out-of SS members was in fact African-Western (Table step 1). Many people have been aged 29–55 ages, college-experienced, and you will working regular. There had been no tall variations in baseline qualities for investigation players across ethnicity or intercourse in both brand new SS otherwise SR organizations (Desk step one).

Baseline SBP, assessed during the screening visit prior to dietary intervention was significantly higher in SS (137.6 ± 8.7 mmHg) vs. SR participants (132.5 ± 9.6 mmHg; p < 0.05, Table 2). In contrast there was no significant difference in 24 h urinary Na + excretion, 24 h urinary K + excretion and the urinary Na + :K + ratio between SS and SR participants at screening (Table 2). Further, there was no significant effect of sex or ethnicity on these variables, as such subsequent analyses were not adjusted for age or ethnicity. In SS, but not SR participants, each additional g/day in urinary Na + excretion across the range of <2 g/day to 5 g/day resulted in a higher SBP value of approximately 1.0 ± 0.4 mmHg in SBP/g Na + excretion (Fig. 2a). The measures >5 g/day Na+ were not included due to increased sample variability. When assessed by linear regression across the entire range of observed Na + excretion we observed no correlation between urinary Na + excretion and SBP in either SS (R 2 = 0.02) or SR (R 2 = 0.02) participants (Fig. 2b). In both SS and SR participants urinary K + excretion of <1 g/day elevated SBP by 3.9 and 4.8 mmHg respectively vs. SBP values obtained for urinary excretion of 1–1.99gK + /day (Fig. 3a) and the Cohen's D score for the difference in the SBP among the participants with less than 1 g/day versus 1-1.9 g/day of urinary K + excretion showed a medium effect size in both SS (0.45) and the SR (0.49) group. However, when assessed across the entire range of observed K + excretion we observed no correlation between K + excretion and SBP in either SS (R 2 = 0.001) or SR (R 2 = 0.008) participants (Fig. 3b). Further, we observed no association between the urinary Na + :K + ratio and SBP and no impact of urinary K + excretion across any dietary Na + excretion range on SBP in either SS (R 2 = 0.004) or SR (R 2 = 0.002) participants (Fig. 4a, b).

Impact out of Dashboard diet plan on the connection out-of urinary salt to help you potassium excretion ratio that have SBP

Within the sub group of SS participants randomly assigned to DASH-Sodium dietary intervention arm (N = 71) there was a significant (p < 0.05) reduction in SBP on the DASH-LS diet compared to the baseline screening SBP value (Table 3). In the sub group of SR participants randomly assigned to the DASH-Sodium intervention (N = 119) there were significant (p < 0.05) reductions in SBP on both the DASH-HS and DASH-LS diets compared to the baseline screening SBP value (Table 3). On the DASH-Sodium diet, following both the LS and HS interventions compared to screening there was a significant (p < 0.05) increase in urinary K + excretion and reduction in the urinary Na + :K + ratio (that was greater during the LS intervention), in both SS and SR participants (Table 3).